Contents

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1. General considerations

2. Virology of hepatitis C

	2.1	Diagnosis of hepatitis C
	2.2	Hepatitis C virus RNA
	2.3	Quantifying hepatitis C virus RNA
	2.4	Genotyping
	2.5	Hepatitis C virus variation and disease

3. Counselling patients with chronic hepatitis

	3.1	General advice
	3.2	Alcohol

4. Transmission and infectivity

	4.1	Sexual transmission
	4.2	Mother to infant transmission
	4.3	Surgeons and other health care professionals

5. Acute hepatitis C

	5.1	Treatment of hepatitis C with interferon alfa
	5.1.1	Advantages
	5.1.2	Disadvantages
	5.2	Treatment

6. Chronic Hepatitis C

	6.1.1	Approach when hepatitis C virus RNA testing is not available
	6.1.2	Approach when hepatitis C virus RNA is available
	6.1.3	Approach when hepatitis C virus RNA measurement and genotyping or serotyping are available
	6.2	Interferon for cirrhosis
	6.3	Treatment of other special groups
	6.4	Side effects of interferon alfa
	6.4.1	Early
	6.4.2	Later - common
	6.4.3	Unusual or severe
	6.4.4	Rare
	6.5	Ribavirin and combination antiviral therapy
	6.6	Other treatments

7. Summary points

8. Bibliography


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